Accede al registro bibliométrico más completo sobre COVID-19. Red Española de Agencias de Evaluación de Tecnologías Sanitarias:
Accede a todos los artículos sobre COVID 19 publicados en NEJM
Generales
World health Organization. Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). 2020 Tanu Singhal. A Review of Coronavirus Disease-2019 (COVID-19). The Indian Journal of Pediatrics. Accepted: 25 February 2020 Jun She , Jinjun Jiang, Ling Ye et al. 2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies. Clin Trans Med (2020) 9:19 Legido-Quigley H, Mateos-García JT, Campos VR, Gea-Sánchez M, Muntaner C, McKee M6. The resilience of the Spanish health system against the COVID-19 pandemic. Lancet Public Health. 2020 Mar 18. pii: S2468-2667(20)30060-8. doi: 10.1016/S2468-2667(20)30060-8. [Epub ahead of print] Kandel N, Chungong S, Omaar A, Xing J. Health security capacities in the context of COVID-19 outbreak: an analysis of International Health Regulations annual report data from 182 countries. Lancet. 2020 Mar 18.
Epidemiología
Field Briefing: Diamond Princess COVID-19 Cases, 20 Feb Update Kampf G, Todt D, Pfaender S, Steinmann E. Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents. J Hosp Infect. 6 de febrero de 2020 World health Organization. Water, sanitation, hygiene and waste management for COVID-19. 2020 Peng Y, Zhou YH. Is novel coronavirus disease (COVID-19) transmitted through conjunctiva? J Med Virol. 2020 Mar 16. doi: 10.1002/jmv.25753 Ryu S1, Chun BC2; Korean Society of Epidemiology 2019-nCoV Task Force Team1. An interim review of the epidemiological characteristics of 2019 novel coronavirus. Epidemiol Health. 2020;42:e2020006. doi: 10.4178/epih.e2020006. Epub 2020 Feb 6 Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, Wang M. Clínica. Presumed Asymptomatic Carrier Transmission of COVID-19. JAMA. 2020 Feb 21. doi: 10.1001/jama.2020.2565 Dong Y, Mo X, Hu Y, et al. Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China. Pediatrics. 2020; doi: 10.1542/peds.2020-0702
Virología
Cui J, Li F, Shi ZL. Origin and evolution of pathogenic coronaviruses Nat Rev Microbiol. 2019 Mar;17(3):181-192. doi: 10.1038/s41579-018-0118-9 Dhama, K.; Sharun, K.; Tiwari, R.; Sircar, S.; Bhat, S.; Malik, Y.S.; Singh, K.P.; Chaicumpa, W.; Bonilla-Aldana, D.K.; Rodriguez-Morales, A.J. Coronavirus Disease 2019 – COVID-19. Origin and evolution of pathogenic coronaviruses. Preprints 2020 Ashour, H.M.; Elkhatib, W.F.; Rahman, M.M.; Elshabrawy, H.A. Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks. Pathogens 2020, 9, 186 Lu R, Zhao X, Li J, Niu P, Yang B, Wu H et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8 Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P et al. Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China Cell Host Microbe. 2020 Mar 11;27(3):325-328. doi: 10.1016/j.chom.2020.02.001 Chen J. Pathogenicity and transmissibility of 2019-nCoVdA quick overview and comparison with other emerging viruses Microbes Infect. 2020 Feb 4. pii: S1286-4579(20)30026-5. doi: 10.1016/j.micinf.2020.01.004 Liu Z, Xiao X, Wei X, Li J, Yang J et al. Composition and divergence of coronavirus spike proteins and hostACE2 receptors predict potential intermediate hosts of SARS‐CoV‐2 J Med Virol. 2020 Feb 26. doi: 10.1002/jmv.25726 Xintian Xu, Ping Chen , Jingfang Wang , Jiannan Feng , Hui Zhon , Xuan Li , Wu Zhong. Evolution of the Novel Coronavirus From the Ongoing Wuhan Outbreak and Modeling of Its Spike Protein for Risk of Human Transmission. Sci China Life Sci, Mar 2020 63 (3), 457-460 Lauer SA, Grantz KH, Bi Q The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application. Ann Intern Med. 2020 Mar 10. doi: 10.7326/M20-0504 Jiang X, Rayner S, Luo MH. Does SARS-CoV-2 has a longer incubation period than SARS and MERS? J Med Virol. 2020 May;92(5):476-478. doi: 10.1002/jmv.25708 van Doremalen N, Bushmaker T, Morris DH, et al. Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1. N Engl J Med. 2020;382(16):1564–1567. doi:10.1056/NEJMc2004973 Grifoni A, Weiskopf D, Ramirez SI, et al. Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals [published online ahead of print, 2020 May 20]. Cell. 2020;S0092-8674(20)30610-3.
Clínica
Fei Zhou, Ting Yu, Ronghui Du et al. Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study. The corrected version first appeared at thelancet.com on March 12, 2020 Chen N, Zhou M, Dong X. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 2020; 395: 507–13 Wang Z, Yang B, Li Q. Clinical Features of 69 Cases with Coronavirus Disease 2019 in Wuhan, China. Published by Oxford University Press for the Infectious Diseases Society of America Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19). J Gen Intern Med. 2020 Mar 4. doi: 10.1007/s11606-020-05762-w Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, Lang C, Huang D, Sun Q, Xiong Y, Huang X, Lv J, Luo Y, Shen L, Yang H, Huang G, Yang R. Clinical Features and Treatment of COVID-19 Patients in Northeast Chongqing. J Med Virol. 2020 Mar 21. doi: 10.1002/jmv.25783 Wu Z McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020; (published online Feb 24.) DOI:10.1001/jama.2020.2648 Zhou F Yu T Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; (published online March 9.) Jinyang Gu, Bing Han, Jian Wang. COVID-19: Gastrointestinal Manifestations and Potential Fecal-Oral Transmission. Gastroenterology, 2020 Mar 3 Long-quan Li, Tian Huang, Yong‐qing Wang et al. 2019 novel coronavirus patients’ clinical characteristics, discharge rate, and fatality rate of meta‐analysis. J Med Virol. 2020;1–7 Lei Pan, Mi Mu, Pengcheng Yang et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Study from The American Journal of Gastroenterology Lechien JR, Chiesa-Estomba CM, De Siati DR, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study [published online ahead of print, 2020 Apr 6]. Eur Arch Otorhinolaryngol. 2020;10.1007/s00405-020-05965-1. doi:10.1007/s00405-020-05965-1
Diagnóstico
Ye-Min Qu, Hai-Yan Cong. Positive result of Sars-Cov-2 in sputum from a cured patient with COVID-19. Travel Medicine and Infectious Disease. In Press, Journal Pre-proof, Available online 8 March 2020, 101619 Ying Zhu , Yang-Li Liu , Zi-Ping Li et al. Clinical and CT imaging features of 2019 novel coronavirus disease (COVID-19). Journal of Infection (26 February 2020) Sharfstein J, Becker S, Mello M. Diagnostic Testing for the Novel Coronavirus. JAMA Published online March 9, 2020 Lippi G, Plebani M. Procalcitonin in patients with severe coronavirus disease 2019 (COVID-19): a meta-analysis. Clinica Chimica Acta (2020). 3 March 2020 Wenjie Yang, Fuhua Yan, Bordi L et al. Patients with RT-PCR Confirmed COVID-19 and Normal Chest CT, on behalf of INMI COVID-19 study group and Collaborating Centers2. Radiology, 200702 2020 Mar 6 Bordi L, Nicastri E, Scorzolini L et al. Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2), Italy, February. 2020. Euro Surveill. 2020;25(8) Organización Mundial de la Salud. Pruebas de laboratorio para el nuevo coronavirus de 2019 (2019-nCoV) en casos sospechosos de infección en humanos. Orientaciones provisionales 17 de enero de 2020 Heshui Shi, Xiaoyu Han, Nanchuan Jiang et al. Radiological findings from 81 patients with COVID-19 pneumonia in Wuhan, China: a descriptive study. Lancet Infect Dis 2020 Gao Y, TuantuanLi, HanM et al. Diagnostic Utility of Clinical Laboratory Data Determinations for Patients with the Severe COVID-19. Aceptado a publicación en Journal of Medical Virology. Doi: 10.1002/jmv.25770 Lippi G, Simundic A and Plebani M. Potential preanalytical and analytical vulnerabilities in the laboratory diagnosis of coronavirus disease 2019 (COVID-19). Clin Chem Lab Med 2020 Soldati G, Smargiassi A, Inchingolo R, Buonsenso D, Perrone T, Briganti DF et al. Is there a role for lung ultrasound during the COVID-19 pandemic? J Ultrasound Med. 2020 Mar 20. doi: 10.1002/jum.15284 SERAM. Guía básica de indicaciones de pruebas de imagen en la infección COVID-19 (V1. 21/3/2020)
Tratamiento
Zhou L1, Liu K, Liu HG. Cause analysis and treatment strategies of “recurrence” with novel coronavirus pneumonia (covid-19) patients after discharge from hospital. Chin J Tuberc Respir Dis, 2020,43:Epub ahead of print Jianjun Gao 1 , Zhenxue Tian 2 , Xu Yang. Breakthrough: Chloroquine Phosphate Has Shown Apparent Efficacy in Treatment of COVID-19 Associated Pneumonia in Clinical Studies. Biosci Trends, 14 (1), 72-73 2020 Mar 16 Andrea Cortegiani , Giulia Ingoglia , Mariachiara Ippolito , Antonino Giarratano , Sharon Einav. A Systematic Review on the Efficacy and Safety of Chloroquine for the Treatment of COVID-19. Crit Care, 2020 Mar 10[Online ahead of print] Anne Catherine Cunningham, Hui Poh Goh , David Koh. Treatment of COVID-19: Old Tricks for New Challenges. Crit Care, 24 (1), 91 2020 Mar 16 Yan-Rong Guo, Qing-Dong Cao, Zhong-Si Hong , Yuan-Yang Tan, Shou-Deng Chen , Hong-Jun Jin , Kai-Sen Tan, De-Yun Wang, Yan Yan. The Origin, Transmission and Clinical Therapies on Coronavirus Disease 2019 (COVID-19) Outbreak – An Update on the Status. Mil Med Res, 7 (1), 11 2020 Mar 13 Bin Cao , Yeming Wang , Danning Wen , Wen Liu , Jingli Wang , Guohui Fan, et al. A Trial of Lopinavir-Ritonavir in Adults Hospitalized With Severe Covid-19. New Engl J Med 2020 Mar 18 C. Cinesi, O Peñuelas, M. Luján, Recomendaciones de consenso respecto al soporte respiratorio no invasivo en el paciente adulto con insuficiencia respiratoria aguda secundaria a infección por SARSCoV- Archivos de Bronconeumología Grupo VMNI SEMES. Recomendación asistencia y soporte respiratorio Covid-19 (2019-nCoV) en transporte sanitario terrestre Zhou D, Dai SM, Tong Q. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression [published online ahead of print, 2020 Mar 20]. J Antimicrob Chemother. 2020;dkaa114. doi:10.1093/jac/dkaa114 Scaravilli V, Grasselli G, Castagna L, et al. Prone positioning improves oxygenation in spontaneously breathing nonintubated patients with hypoxemic acute respiratory failure: A retrospective study. J Crit Care. 2015;30(6):1390–1394. doi:10.1016/j.jcrc.2015.07.008 Hersey D, Witter T, Kovacs G. Transport of a Prone Position Acute Respiratory Distress Syndrome Patient. Air Med J. 2018;37(3):206–210. doi:10.1016/j.amj.2018.02.003 Gautret P, Lagier JC, Parola P, et al. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: A pilot observational study [published online ahead of print, 2020 Apr 11]. Travel Med Infect Dis. 2020;101663. doi:10.1016/j.tmaid.2020.101663 Cook TM, El-Boghdadly K, McGuire B, McNarry AF, Patel A, Higgs A. Consensus guidelines for managing the airway in patients with COVID-19: Guidelines from the Difficult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetists. Anaesthesia. 2020;75(6):785‐799. Kolilekas L, Loverdos K, Giannakaki S, et al. Can steroids reverse the severe COVID-19 induced ‘cytokine storm’? J Med Virol. 2020. https://www.ncbi.nlm.nih.gov/pubmed/32530507. Fadel R, Morrison AR, Vahia A, et al. Early short course corticosteroids in hospitalized patients with COVID-19. Clin Infect Dis. 2020. https://www.ncbi.nlm.nih.gov/pubmed/32427279. So C, Ro S, Murakami M, Imai R, Jinta T. High-dose, short-term corticosteroids for ARDS caused by COVID-19: a case series. Respirol Case Rep. 2020;8(6):e00596. https://www.ncbi.nlm.nih.gov/pubmed/32514354. Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med. 2020. https://www.ncbi.nlm.nih.gov/pubmed/32167524. Yuan M, Xu X, Xia D, et al. Effects of corticosteroid treatment for non-severe COVID-19 pneumonia: a propensity score-based analysis. Shock. 2020. https://www.ncbi.nlm.nih.gov/pubmed/32496422. Yang Z, Liu J, Zhou Y, Zhao X, Zhao Q, Liu J. The effect of corticosteroid treatment on patients with coronavirus infection: a systematic review and meta-analysis. J Infect. 2020;81(1):e13-e20. https://www.ncbi.nlm.nih.gov/pubmed/32283144. Randomised Evaluation of COVID-19 Therapy (RECOVERY). Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19. 2020. https://www.recoverytrial.net/news/low-cost-dexamethasone-reduces-death-by-up-to-one-third-in-hospitalised-patients-with-severe-respiratory-complications-of-covid-19. Horby P, Shen Lim W, Emberson J, et al. Effect of dexamethasone in hospitalized patients with COVID-19: preliminary report. medRxiv. 2020;[Preprint].https://www.medrxiv.org/content/10.1101/2020.06.22.20137273v1. Arabi YM, Mandourah Y, Al-Hameed F, et al. Corticosteroid therapy for critically ill patients with Middle East Respiratory Syndrome. Am J Respir Crit Care Med. 2018;197(6):757-767. https://www.ncbi.nlm.nih.gov/pubmed/29161116.
Predictores de gravedad
Chen W, Lan Y, Yuan X. Detectable 2019-nCoV viral RNA in blood is a strong indicator for the further clinical severity. Emerging Microbes & Infections, 9:1, 469-473 Lippi G, Plebani M, Michael Henry B. Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clinica Chimica Acta (2020) Zhou F Yu T Du R et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020; (published online March 9.) Lin Din, Li Wan, Wanhong Ma, Hangyong He. Efficacy and Safety of Early Prone Positioning Combined With HFNC or NIV in Moderate to Severe ARDS: A Multi-Center Prospective Cohort Study. Crit Care, 24 (1), 28 2020 Jan 30 Chen R, Liang W, Jiang M, et al. Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China [published online ahead of print, 2020 Apr 15]. Chest. 2020;S0012-3692(20)30710-8. doi:10.1016/j.chest.2020.04.010
Complicaciones
Zeng, J.H.; Liu, Y.; Yuan, J, et al. First Case of COVID-19 Infection with Fulminant Myocarditis Complication: Case Report and Insights. Preprints 2020, 2020030180 (doi: 10.20944/preprints202003.0180.v1) He XW, Lai JS, et al. Impact of complicated myocardial injury on the clinical outcome of severe or critically ill COVID-19 patients. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Mar 15;48(0):E011. doi: 10.3760/cma.j.cn112148-20200228-00137 Han, H., Yang, L., Liu, R., et al. (2020). Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinical Chemistry and Laboratory Medicine (CCLM), 0(0), pp. -. Retrieved 19 Mar. 2020, from doi:10.1515/cclm-2020-0188 Xu, D.; Zhang, H.; Gong, H.; Chen, J.; Ye, J.; Meng, T.; Gan, S.; Qu, F.; Chu, C.; Zhou, W.; Pan, X.; Wang, L.; Cui, X. Identification of a Potential Mechanism of Acute Kidney Injury During the Covid-19 Outbreak: A Study Based on Single-Cell Transcriptome Analysis. Preprints 2020, 2020020331 Wang T, Du Z et al Comorbidities and multi-organ injuries in the treatment of COVID19. Lancet. 2020 Mar 11. pii: S0140-6736(20)30558-4 Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients [published online ahead of print, 2020 Feb 27]. J Med Virol. 2020;10.1002/jmv.25728. doi:10.1002/jmv.25728 Fried JA, Ramasubbu K, Bhatt R, et al. The Variety of Cardiovascular Presentations of COVID-19 [published online ahead of print, 2020 Apr 3]. Circulation. 2020;10.1161/CIRCULATIONAHA.120.047164. doi:10.1161/CIRCULATIONAHA.120.047164 Lazzerini PE, Boutjdir M, Capecchi PL. COVID-19, Arrhythmic Risk and Inflammation: Mind the Gap! [published online ahead of print, 2020 Apr 14]. Circulation. 2020;10.1161/CIRCULATIONAHA.120.047293. doi:10.1161/CIRCULATIONAHA.120.047293
Embarazo
Alzamora MC, Paredes T, Caceres D, Webb CM, Valdez LM, La Rosa M. Severe COVID-19 during Pregnancy and Possible Vertical Transmission [published online ahead of print, 2020 Apr 18]. Am J Perinatol. 2020;10.1055/s-0040-1710050. doi:10.1055/s-0040-1710050 Panahi L, Amiri M, Pouy S. Risks of Novel Coronavirus Disease (COVID-19) in Pregnancy; a Narrative Review. Arch Acad Emerg Med. 2020;8(1):e34. Published 2020 Mar 23. Schwartz DA. An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes [published online ahead of print, 2020 Mar 17]. Arch Pathol Lab Med. 2020;10.5858/arpa.2020-0901-SA. doi:10.5858/arpa.2020-0901-SA Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know [published online ahead of print, 2020 Feb 24]. Am J Obstet Gynecol. 2020;S0002-9378(20)30197-6. Chen H, Guo J, Wang C, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records [published correction appears in Lancet. 2020 Mar 28;395(10229):1038] [published correction appears in Lancet. 2020 Mar 28;395(10229):1038]. Lancet. 2020;395(10226):809–815. doi:10.1016/S0140-6736(20)30360-3 Zaigham M, Andersson O. Maternal and Perinatal Outcomes with COVID-19: a systematic review of 108 pregnancies [published online ahead of print, 2020 Apr 7]. Acta Obstet Gynecol Scand. 2020;10.1111/aogs.13867. doi:10.1111/aogs.13867 Martinez-Portilla RJ, Goncé A, Hawkins-Villarreal A, Figueras F. A Spanish-translated clinical algorithm for management of suspected SARS-CoV-2 infection in pregnant women [published online ahead of print, 2020 Apr 9]. Lancet Infect Dis. 2020;S1473-3099(20)30285-1. doi:10.1016/S1473-3099(20)30285-1
Impacto psicológico
Lima, C. K. T., Carvalho, P. M. de M., Lima, I. de A. S., Nunes, J. V. A. de O., Saraiva, J. S., de Souza, R. I et al. The Emotional Impact Of Coronavirus 2019-Ncov (New Coronavirus Disease). Psychiatry Research, 2020, 112915. doi:10.1016/j.psychres.2020.112915
Organización Mundial de la Salud
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